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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AP2B1 All Species: 41.82
Human Site: S514 Identified Species: 92
UniProt: P63010 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P63010 NP_001025177.1 937 104553 S514 L S L A T Q D S D N P D L R D
Chimpanzee Pan troglodytes XP_001174136 940 104904 S514 L S L A T Q D S D N P D L R D
Rhesus Macaque Macaca mulatta XP_001105809 939 103490 S514 L S L A T Q D S D N P D L R D
Dog Lupus familis XP_867819 948 105775 S525 L S L A T Q D S D N P D L R D
Cat Felis silvestris
Mouse Mus musculus Q9DBG3 937 104564 S514 L S L A T Q D S D N P D L R D
Rat Rattus norvegicus P62944 937 104534 S514 L S L A T Q D S D N P D L R D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521247 904 100060 S501 L S L A T Q D S D N P D L R D
Chicken Gallus gallus XP_415772 951 105633 S514 L S L A T Q D S D N P D L R D
Frog Xenopus laevis NP_001080473 951 105601 S514 L S L A T Q D S D N P D L R D
Zebra Danio Brachydanio rerio NP_956213 951 105606 S514 L S L A T Q D S D N P D L R D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P36000 726 81850 Y345 V K F N D P L Y V K L E K I D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 84 98.7 N.A. 99.8 100 N.A. 90.8 97.4 95.2 93.2 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.6 92.4 98.8 N.A. 99.8 100 N.A. 92.5 98.2 96.8 95.9 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 100 100 100 100 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 100 100 100 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 31.3 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 48.2 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 91 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 10 0 91 0 91 0 0 91 0 0 100 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % E
% Phe: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % I
% Lys: 0 10 0 0 0 0 0 0 0 10 0 0 10 0 0 % K
% Leu: 91 0 91 0 0 0 10 0 0 0 10 0 91 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 10 0 0 0 0 0 91 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 10 0 0 0 0 91 0 0 0 0 % P
% Gln: 0 0 0 0 0 91 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 91 0 % R
% Ser: 0 91 0 0 0 0 0 91 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 91 0 0 0 0 0 0 0 0 0 0 % T
% Val: 10 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _